Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 2/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | DNM1L | O00429 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL245525 | 0.78 | PSIP1 (0.43) | EZH2PSMB5PSMB1 | |
| SCHEMBL244658 | 0.78 | PSIP1 (0.43) | EZH2PSMB5PSMB1 | |
| SCHEMBL27928163 | 0.77 | EZH2 (0.34) | EZH2PSMB5 | |
| SCHEMBL27928096 | 0.76 | EZH2 (0.34) | EZH2CSF1R | |
| SCHEMBL3299227 | 0.75 | PSIP1 (0.35) | EZH2PSMB5 | |
| SCHEMBL15182616 | 0.75 | PSIP1 (0.35) | EZH2PSMB5PSMB1 | |
| SCHEMBL27910441 | 0.74 | SMYD3 (0.35) | PSMB5PSMB1GRM2SMN1; SMN2KDM4E | |
| SCHEMBL18891991 | 0.72 | GRM2 (0.41) | GRM2SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL27903912 | 0.71 | PTPN11 (0.37) | LMNAMAPTKDM4E | |
| SCHEMBL246450 | 0.67 | PSIP1 (0.45) | PSMB5PSMB1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588455-B1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES INC (US) | 2018-04-04 | — | — | EP | disclosed |