Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11985956 | 0.82 | POLB (0.46) | MAPTKMT2AOPRK1POLBKDM4E | |
| SCHEMBL244694 | 0.81 | MAPT (0.41) | MAPTKMT2AOPRK1POLBKDM4E | |
| Bromide SCHEMBL15093306 | 0.80 | MAPT (0.40) | MAPTKMT2AOPRK1POLBKDM4E | |
| SCHEMBL14029004 | 0.76 | KMT2A (0.50) | MAPTKMT2AOPRK1POLBKDM4E | |
| SCHEMBL247091 | 0.74 | POLB (0.47) | MAPTPOLBGAACYP1A2NR4A2 | |
| SCHEMBL11985964 | 0.73 | POLB (0.50) | MAPTKMT2AOPRK1POLBKDM4E | |
| SCHEMBL11985971 | 0.73 | POLB (0.42) | MAPTKMT2AOPRK1POLBKDM4E | |
| SCHEMBL11985978 | 0.73 | POLB (0.42) | MAPTKMT2AOPRK1POLBKDM4E | |
| SCHEMBL4177223 | 0.72 | ALDH1A1 (0.51) | MAPTKMT2AOPRK1POLBKDM4E | |
| SCHEMBL862762 | 0.71 | ALDH1A1 (0.55) | MAPTKMT2AOPRK1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588455-B1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES INC (US) | 2018-04-04 | — | — | EP | disclosed |