Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 17/20 | 0.53 |
| ▸ | CTSK | P43235 | 15/20 | 0.53 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239063 | 0.88 | CTSS (0.48) | CTSSCTSKCTSLCTSB | |
| SCHEMBL5170834 | 0.83 | CTSS (0.61) | CTSSCTSKCTSLCTSBSYK | |
| SCHEMBL1993119 | 0.81 | CTSS (0.46) | CTSSCTSKSYKSERPINE1 | |
| SCHEMBL21359172 | 0.81 | CTSS (0.39) | CTSSCTSKCTSLCTSB | |
| SCHEMBL3651290 | 0.81 | CTSS (0.46) | CTSSCTSKCTSLCTSBSYK | |
| SCHEMBL3654576 | 0.81 | CTSS (0.46) | CTSSCTSKCTSLCTSBSYK | |
| SCHEMBL10376395 | 0.80 | CTSS (0.45) | CTSSCTSKSYKSERPINE1 | |
| SCHEMBL10321617 | 0.80 | CTSS (0.45) | CTSSCTSKSYKSERPINE1 | |
| SCHEMBL115752 | 0.79 | CTSS (0.46) | CTSSCTSKCTSLCTSBSYK | |
| SCHEMBL19256882 | 0.78 | CTSS (0.43) | CTSSCTSKSYKSERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765449-A1 | AMINO-BENZOISOTHIAZOLE AND AMINO-BENZOISOTHIADIAZOLE AMIDE COMPOUNDS | Aerie Pharmaceuticals, Inc. (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019178324-A1 | AMINO-BENZOISOTHIAZOLE AND AMINO-BENZOISOTHIADIAZOLE AMIDE COMPOUNDS | AERIE PHARMACEUTICALS, INC. (US) | 2019-09-19 | — | — | WO | disclosed |
| EP-2326623-A2 | BETA-AND GAMMA-AMINO-ISOQUINOLINE AMIDE COMPOUNDS AND SUBSTITUTED BENZAMIDE COMPOUNDS | Aerie Pharmaceuticals, Inc. (US) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010011853-A2 | BETA-AND GAMMA-AMINO-ISOQUINOLINE AMIDE COMPOUNDS AND SUBSTITUTED BENZAMIDE COMPOUNDS | AERIE PHARMACEUTICALS, INC. (US) | 2010-01-28 | — | — | WO | disclosed |