Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3321643 | 0.81 | KDM4E (0.48) | KDM4ESMN1; SMN2GRM2PTGDR2LMNA | |
| SCHEMBL3297610 | 0.80 | KDM4E (0.54) | KDM4ESMN1; SMN2GRM2PTGDR2LMNA | |
| SCHEMBL10284333 | 0.80 | KDM4E (0.47) | KDM4ESMN1; SMN2LMNACYP1A2CYP2C19 | |
| SCHEMBL3303954 | 0.79 | KDM4E (0.53) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL20021122 | 0.78 | KDM4E (0.52) | KDM4ESMN1; SMN2GRM2PTGDR2LMNA | |
| SCHEMBL20020768 | 0.78 | CNR1 (0.45) | KDM4ESMN1; SMN2PTGDR2ALDH1A1 | |
| SCHEMBL3323941 | 0.77 | KDM4E (0.51) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL10284334 | 0.77 | KDM4E (0.49) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL20020760 | 0.77 | KDM4E (0.48) | KDM4ESMN1; SMN2PTGDR2LMNACYP1A2 | |
| SCHEMBL3324004 | 0.77 | KDM4E (0.48) | KDM4ESMN1; SMN2PTGDR2LMNADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588455-B1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES INC (US) | 2018-04-04 | — | — | EP | disclosed |