SCHEMBL20021614

SCHEMBL20021614

[N-]=[N+]=NCOC1CC(n2cc(C#CCNC(=O)COCCOC(COc3cccc(C(=O)NCCN)c3)N=[N+]=[N-])c(N)nc2=O)OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ P2RY2 P41231 2/20 0.32
▸ POLG P54098 1/20 0.32
▸ P2RY4 P51582 1/20 0.31
▸ P2RY6 Q15077 1/20 0.31
▸ POLB P06746 1/20 0.30
▸ POLA1 P09884 1/20 0.30
▸ POLD1 P28340 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20383456 1.00 P2RY2 (0.32) P2RY2POLGP2RY4P2RY6POLB
SCHEMBL20387883 1.00 P2RY2 (0.32) P2RY2POLGP2RY4P2RY6POLB
SCHEMBL14820564 1.00 P2RY2 (0.32) P2RY2POLGP2RY4P2RY6POLB
SCHEMBL14806824 1.00 P2RY2 (0.32) P2RY2POLGP2RY4P2RY6POLB
SCHEMBL20387895 0.96 P2RY2 (0.32) P2RY2POLGP2RY4P2RY6
SCHEMBL19569898 0.96 P2RY2 (0.32) P2RY2POLGP2RY4P2RY6
SCHEMBL20329770 0.95 P2RY2 (0.33) P2RY2POLGP2RY4P2RY6POLB
SCHEMBL14392447 0.95 P2RY2 (0.32) P2RY2POLGP2RY4P2RY6
SCHEMBL20821471 0.94 P2RY2 (0.32) P2RY2P2RY4P2RY6
SCHEMBL17227493 0.94 P2RY2 (0.32) P2RY2P2RY4P2RY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10844225-B2 Fluorescent dyes and their uses as biomarkers ILLUMINA CAMBRIDGE LIMITED (GB) 2020-11-24 — — US disclosed
US-10385214-B2 Fluorescent dyes and their uses as biomarkers ILLUMINA CAMBRIDGE LIMITED (GB) 2019-08-20 — — US disclosed
US-20180094140-A1 FLUORESCENT DYES AND THEIR USES AS BIOMARKERS ILLUMINA CAMBRIDGE LIMITED (GB) 2018-04-05 — — US disclosed
US-20180094140-A1 FLUORESCENT DYES AND THEIR USES AS BIOMARKERS ILLUMINA CAMBRIDGE LIMITED (GB) 2018-04-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844225-B2 Fluorescent dyes and their uses as biomarkers FBL, HNRNPF, EWSR1 P2RY2 1965/4885POLG 983/4885P2RY4 1622/4885
US-10385214-B2 Fluorescent dyes and their uses as biomarkers FBL, EWSR1, HNRNPF P2RY2 2115/4885POLG 889/4885P2RY4 1660/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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