SCHEMBL20022145

SCHEMBL20022145

Cc1cccc(-c2cccc(-c3cccc(-c4ccccc4C(F)(F)F)c3)c2)c1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 5/20 0.54
AR P10275 2/20 0.53
PDK2 Q15119 1/20 0.49
TRPA1 O75762 4/20 0.48
HSD11B1 P28845 4/20 0.47
ENPP1 P22413 1/20 0.47
PTPN5 P54829 1/20 0.46
BACE1 P56817 1/20 0.43
TRPM8 Q7Z2W7 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20022130 1.00 SCN9A (0.54) SCN9AARPDK2TRPA1HSD11B1
SCHEMBL5540262 0.96 SCN9A (0.53) SCN9AARPDK2TRPA1HSD11B1
SCHEMBL20022111 0.95 AR (0.51) SCN9AARPDK2TRPA1HSD11B1
SCHEMBL30146607 0.85 SCN9A (0.59) SCN9AARTRPA1HSD11B1BACE1
SCHEMBL5114438 0.82 AR (0.51) SCN9AARPDK2TRPA1HSD11B1
SCHEMBL27874356 0.81 PDK2 (0.48) SCN9AARPDK2TRPA1ENPP1
SCHEMBL27638539 0.81 AR (0.59) ARPDK2HSD11B1PTPN5
SCHEMBL6254521 0.79 AR (0.43) SCN9AARPDK2TRPA1HSD11B1
SCHEMBL25011712 0.78 CYP2C9 (0.50) SCN9AARPDK2ENPP1PTPN5
SCHEMBL29890197 0.78 AR (0.48) ARPDK2HSD11B1ENPP1PTPN5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11136341-B2 Polycyclic aromatic compound and light emission layer-forming composition KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2021-10-05 US disclosed
US-10689402-B2 Polycyclic aromatic compound and light emission layer-forming composition JNC CORPORATION (JP) 2020-06-23 US disclosed
US-20200190116-A1 POLYCYCLIC AROMATIC COMPOUND AND LIGHT EMISSION LAYER-FORMING COMPOSITION KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2020-06-18 US disclosed
US-20180094000-A1 POLYCYCLIC AROMATIC COMPOUND AND LIGHT EMISSION LAYER-FORMING COMPOSITION KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2018-04-05 US disclosed
US-20180094000-A1 POLYCYCLIC AROMATIC COMPOUND AND LIGHT EMISSION LAYER-FORMING COMPOSITION KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2018-04-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200190116-A1 POLYCYCLIC AROMATIC COMPOUND AND LIGHT EMISSION LAYER-FORMING COMPOSITION TYR, NOD2, AHR SCN9A 2866/4885AR 1475/4885PDK2 4751/4885
US-11136341-B2 Polycyclic aromatic compound and light emission layer-forming composition TYR, NOD2, AHR SCN9A 2866/4885AR 1475/4885PDK2 4751/4885
US-20180094000-A1 POLYCYCLIC AROMATIC COMPOUND AND LIGHT EMISSION LAYER-FORMING COMPOSITION TYR, NOD2, AHR SCN9A 2866/4885AR 1475/4885PDK2 4751/4885
US-10689402-B2 Polycyclic aromatic compound and light emission layer-forming composition TYR, NOD2, AHR SCN9A 2866/4885AR 1475/4885PDK2 4751/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.