Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.78 |
| ▸ | RAB9A | P51151 | 9/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12164813 | 0.90 | NPC1 (0.78) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL718420 | 0.88 | NPC1 (0.60) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL31728405 | 0.87 | NPC1 (0.59) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL168643 | 0.85 | NPC1 (1.00) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL31729132 | 0.83 | NPC1 (0.54) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL23459914 | 0.82 | NPC1 (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6175085 | 0.80 | CA12 (0.62) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL11765154 | 0.79 | RAB9A (0.62) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL23456902 | 0.79 | NPC1 (0.51) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL18163568 | 0.78 | NPC1 (0.49) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025235874-A1 | HETEROCYCLICS AS EGFR INHIBITORS | SCHRÖDINGER, INC. (US) | 2025-11-13 | — | — | WO | disclosed |
| US-20210163448-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF AXL/MER RTK AND CSF1R | QURIENT CO., LTD. (KR) | 2021-06-03 | — | — | US | disclosed |
| US-10934274-B2 | Quinoline derivatives as TAM RTK inhibitors | QURIENT CO., LTD. (KR) | 2021-03-02 | — | — | US | disclosed |
| EP-3286177-B1 | QUINOLINE DERIVATIVES AS TAM RTK INHIBITORS | QURIENT CO LTD (KR) | 2020-05-06 | — | — | EP | disclosed |
| US-20180093968-A1 | QUINOLINE DERIVATIVES AS TAM RTK INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2018-04-05 | — | — | US | disclosed |
| US-20180093968-A1 | QUINOLINE DERIVATIVES AS TAM RTK INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163448-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF AXL/MER RTK AND CSF1R | CSF1R, CSF3R, FLT3 | NPC1 4073/4885RAB9A 1316/4885ALDH1A1 3654/4885 |
| US-10934274-B2 | Quinoline derivatives as TAM RTK inhibitors | TYRO3, MERTK, AXL | NPC1 4765/4885RAB9A 1111/4885ALDH1A1 3954/4885 |
| US-20180093968-A1 | QUINOLINE DERIVATIVES AS TAM RTK INHIBITORS | TYRO3, MERTK, AXL | NPC1 4765/4885RAB9A 1111/4885ALDH1A1 3954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.