Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.38 |
| ▸ | RXRA | P19793 | 5/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | FER | P16591 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164749 | 0.82 | AURKA (0.51) | NR3C2GRIN2BRXRAGRIN1KDM4E | |
| Hydrochloric Acid SCHEMBL30297750 | 0.81 | AURKA (0.51) | NR3C2GRIN2BRXRAGRIN1KDM4E | |
| SCHEMBL168701 | 0.77 | SCN9A (0.40) | HDAC9NR3C2GRIN2BRXRAGRIN1 | |
| SCHEMBL30108354 | 0.76 | ALDH1A1 (0.52) | ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL3946970 | 0.76 | ALDH1A1 (0.52) | ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL23749349 | 0.76 | AURKA (0.46) | HDAC9GRIN2BRXRAGRIN1KDM4E | |
| SCHEMBL30030359 | 0.76 | AURKA (0.46) | HDAC9GRIN2BRXRAGRIN1KDM4E | |
| Hydrochloric Acid SCHEMBL28402210 | 0.75 | AURKA (0.45) | HDAC9GRIN2BRXRAGRIN1KDM4E | |
| SCHEMBL30031094 | 0.75 | AURKA (0.45) | HDAC9GRIN2BRXRAGRIN1ALDH1A1 | |
| SCHEMBL23749363 | 0.75 | AURKA (0.45) | HDAC9GRIN2BRXRAGRIN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093968-A1 | QUINOLINE DERIVATIVES AS TAM RTK INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093968-A1 | QUINOLINE DERIVATIVES AS TAM RTK INHIBITORS | TYRO3, MERTK, AXL | HDAC9 3016/4885NR3C2 2586/4885GRIN2B 2737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.