Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CETP | P11597 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20023007 | 1.00 | TSHR (0.61) | TSHRALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL20023006 | 1.00 | TSHR (0.61) | TSHRALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL9562211 | 0.98 | ALDH1A1 (0.63) | TSHRALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL9790736 | 0.93 | ALDH1A1 (0.69) | TSHRALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL8945466 | 0.90 | TSHR (0.67) | TSHRALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL28476399 | 0.90 | TSHR (0.67) | TSHRALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL18990497 | 0.90 | TSHR (0.67) | TSHRALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL7107538 | 0.90 | TSHR (0.67) | TSHRALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL28102570 | 0.90 | TSHR (0.67) | TSHRALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL28154418 | 0.90 | TSHR (0.67) | TSHRALDH1A1CYP3A4MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093981-A1 | 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors | GENZYME CORPORATION | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093981-A1 | 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors | ASAH2, GBA1, GAA | TSHR 2541/4885ALDH1A1 961/4885CYP3A4 4407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.