Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18128887 | 0.85 | GCK (0.42) | NOTUMMCHR1 | |
| SCHEMBL5090920 | 0.84 | CHRNB2 (0.43) | CHRM4AKR1C3CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL5096829 | 0.84 | CHRNB2 (0.43) | CHRM4AKR1C3CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL5096831 | 0.84 | CHRNB2 (0.43) | CHRM4AKR1C3CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL5090914 | 0.84 | CHRNB2 (0.43) | CHRM4AKR1C3CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL16399141 | 0.81 | MAPT (0.53) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT | |
| SCHEMBL16399143 | 0.81 | MAPT (0.53) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT | |
| SCHEMBL3939344 | 0.81 | NPY5R (0.34) | NOTUMMCHR1 | |
| SCHEMBL16398200 | 0.80 | MCHR1 (0.40) | CHRNB2CHRNA4NOTUMMCHR1 | |
| SCHEMBL22499863 | 0.79 | HRH3 (0.48) | CHRM4NOTUMMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960380-B2 | Non-anilinic derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators | ASTRAZENECA AB (SE) | 2011-06-14 | — | — | US | disclosed |