Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22897209 | 0.90 | MAPT (0.68) | MAPTALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL20028137 | 0.86 | TP53 (0.49) | MAPTALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL20028059 | 0.86 | MAPT (0.57) | MAPTALDH1A1HPGDKMT2AGAA | |
| SCHEMBL20028202 | 0.85 | MAPT (0.55) | MAPTALDH1A1HPGDKMT2AGAA | |
| SCHEMBL20028525 | 0.85 | MAPT (0.55) | MAPTALDH1A1HPGDKMT2AGAA | |
| SCHEMBL22896939 | 0.84 | MAPT (0.55) | MAPTALDH1A1HPGDL3MBTL1SMN1; SMN2 | |
| SCHEMBL22896512 | 0.84 | MAPT (0.55) | MAPTALDH1A1HPGDKMT2AL3MBTL1 | |
| SCHEMBL20027618 | 0.82 | MAPT (0.52) | MAPTALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL20027869 | 0.81 | MAPT (0.52) | MAPTALDH1A1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL20028524 | 0.81 | KMT2A (0.60) | MAPTALDH1A1HPGDCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | MAPT 562/4885ALDH1A1 4193/4885HPGD 2346/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | MAPT 330/4885ALDH1A1 4421/4885HPGD 2414/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | MAPT 562/4885ALDH1A1 4193/4885HPGD 2346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.