Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCAF1 | Q9Y4B6 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20028239 | 0.84 | DCAF1 (0.46) | DCAF1CA12CA9CA1CA2 | |
| SCHEMBL20027902 | 0.83 | DCAF1 (0.52) | DCAF1CA12CA9CA1CA2 | |
| SCHEMBL20028623 | 0.83 | DCAF1 (0.53) | DCAF1KDM5BIRAK4KLKB1KLK1 | |
| SCHEMBL22896963 | 0.83 | DCAF1 (0.53) | DCAF1KDM5BIRAK4KLKB1KLK1 | |
| SCHEMBL20028241 | 0.81 | DCAF1 (0.50) | DCAF1CA12CA9CA1CA2 | |
| SCHEMBL20027914 | 0.80 | DCAF1 (0.48) | DCAF1CA12CA9CA1CA2 | |
| SCHEMBL22897243 | 0.79 | DCAF1 (0.51) | DCAF1CA12CA9CA1CA2 | |
| SCHEMBL20027718 | 0.79 | DCAF1 (0.51) | DCAF1CA12CA9CA1CA2 | |
| SCHEMBL22897214 | 0.78 | DCAF1 (0.51) | DCAF1KLKB1KLK1F2F10 | |
| SCHEMBL20028717 | 0.77 | DCAF1 (0.50) | DCAF1KLKB1KLK1F2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |