Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCAF1 | Q9Y4B6 | 1/20 | 0.51 |
| ▸ | PYGL | P06737 | 8/20 | 0.47 |
| ▸ | CTSV | O60911 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22897243 | 1.00 | DCAF1 (0.51) | DCAF1PYGLCTSVCTSLCTSS | |
| SCHEMBL20027723 | 0.91 | PYGL (0.52) | DCAF1PYGLCTSVCTSLCTSS | |
| SCHEMBL20027722 | 0.87 | DCAF1 (0.48) | DCAF1CTSVCTSLCTSSCTSK | |
| SCHEMBL22897214 | 0.87 | DCAF1 (0.51) | DCAF1PYGLCTSVCTSLCTSS | |
| SCHEMBL20027914 | 0.86 | DCAF1 (0.48) | DCAF1PYGLKMT2AMEN1ALDH1A1 | |
| SCHEMBL20028717 | 0.84 | DCAF1 (0.50) | DCAF1PYGLCTSVCTSLCTSS | |
| SCHEMBL22886500 | 0.82 | DCAF1 (0.54) | DCAF1CTSVCTSLCTSSCTSK | |
| SCHEMBL22886627 | 0.82 | PYGL (0.48) | DCAF1PYGLCTSVCTSLCTSS | |
| SCHEMBL22885968 | 0.82 | DCAF1 (0.49) | DCAF1PYGLCTSVCTSLCTSS | |
| SCHEMBL22885969 | 0.81 | DCAF1 (0.48) | DCAF1PYGLCTSVCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |