Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20470659 | 0.81 | ALDH1A1 (0.57) | KDM4EHPGDALDH1A1HTTRECQL | |
| SCHEMBL26918509 | 0.79 | KDM4E (0.48) | KDM4EHPGDALDH1A1HTTRECQL | |
| SCHEMBL2826264 | 0.79 | ALDH1A1 (0.54) | KDM4EHPGDALDH1A1HTTRECQL | |
| SCHEMBL15556252 | 0.79 | KDM4E (0.54) | KDM4EHPGDALDH1A1HTTRECQL | |
| SCHEMBL11042567 | 0.79 | KDM4E (0.54) | KDM4EHPGDALDH1A1HTTRECQL | |
| SCHEMBL2823520 | 0.79 | KDM4E (0.54) | KDM4EHPGDALDH1A1HTTRECQL | |
| SCHEMBL2823753 | 0.76 | KDM4E (0.51) | KDM4EHPGDALDH1A1HTTRECQL | |
| SCHEMBL2821727 | 0.75 | ALDH1A1 (0.54) | KDM4EHPGDALDH1A1HTTRECQL | |
| SCHEMBL2823066 | 0.75 | ALDH1A1 (0.54) | KDM4EHPGDALDH1A1HTTRECQL | |
| SCHEMBL13743161 | 0.73 | ALDH1A1 (0.47) | KDM4EHPGDALDH1A1HTTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |