Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.52 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | DHPS | P49366 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1500111 | 0.88 | HDAC1 (0.49) | HDAC1HDAC4HDAC6ALDH1A1ALDH2 | |
| SCHEMBL31667003 | 0.87 | HDAC1 (0.48) | HDAC1HDAC4HDAC6HDAC7ACHE | |
| SCHEMBL24878857 | 0.86 | GRM5 (0.56) | HDAC1HDAC4HDAC6ALDH1A1ALDH2 | |
| SCHEMBL16850291 | 0.85 | HDAC1 (0.58) | HDAC1HDAC4HDAC6HDAC7DHPS | |
| SCHEMBL2019162 | 0.84 | HDAC1 (0.56) | HDAC1HDAC4HDAC6ALDH1A1ALDH2 | |
| SCHEMBL2020917 | 0.83 | PARP1 (0.49) | HDAC1HDAC4HDAC6ALDH1A1ALDH2 | |
| SCHEMBL20773874 | 0.82 | PARK7 (0.50) | HDAC1HDAC4HDAC6HDAC7MEN1 | |
| SCHEMBL29507053 | 0.82 | PARK7 (0.50) | HDAC1HDAC4HDAC6HDAC7MEN1 | |
| SCHEMBL15120603 | 0.82 | HDAC1 (0.55) | HDAC1HDAC4HDAC6HDAC7DHPS | |
| SCHEMBL31391661 | 0.82 | KDM4E (0.55) | HDAC1HDAC4HDAC6ALDH1A1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357484-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-07-23 | — | — | US | disclosed |
| US-20190008836-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-01-10 | — | — | US | disclosed |
| EP-3327019-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-05-30 | — | — | EP | disclosed |
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10357484-B2 | Heterocyclic compound | HDAC1, HDAC11, HDAC5 | HDAC1 1/4885HDAC4 9/4885HDAC6 7/4885 |
| US-20190008836-A1 | HETEROCYCLIC COMPOUND | HDAC1, HDAC11, HDAC5 | HDAC1 1/4885HDAC4 9/4885HDAC6 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.