Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 6/20 | 0.36 |
| ▸ | CTSD | P07339 | 5/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.36 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21854167 | 0.84 | CAPN1 (0.49) | NPC1RAB9ASMN1; SMN2CAPN1 | |
| SCHEMBL21854168 | 0.84 | CAPN1 (0.49) | NPC1RAB9ASMN1; SMN2CAPN1 | |
| SCHEMBL20028029 | 0.79 | PIN1 (0.45) | NPC1RAB9AKMT2A | |
| SCHEMBL20028023 | 0.79 | PIN1 (0.45) | NPC1RAB9AKMT2A | |
| SCHEMBL22897297 | 0.78 | CAPN1 (0.42) | CAPN1 | |
| SCHEMBL30133621 | 0.78 | CAPN1 (0.42) | CAPN1 | |
| SCHEMBL20028635 | 0.78 | CAPN1 (0.42) | CAPN1 | |
| SCHEMBL21854362 | 0.77 | CAPN1 (0.49) | CAPN1 | |
| SCHEMBL20027528 | 0.77 | CAPN1 (0.49) | CAPN1 | |
| SCHEMBL20027515 | 0.76 | BACE1 (0.37) | BACE1CTSDBACE2TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |