Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 11/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23268997 | 1.00 | CAPN1 (0.54) | CAPN1ALDH1A1MAPTTSHRCTSS | |
| SCHEMBL20028561 | 0.95 | CAPN1 (0.54) | CAPN1ALDH1A1MAPT | |
| SCHEMBL21854059 | 0.95 | CAPN1 (0.54) | CAPN1ALDH1A1MAPT | |
| SCHEMBL21854326 | 0.94 | CAPN1 (0.51) | CAPN1ALDH1A1MAPTCTSS | |
| SCHEMBL20027837 | 0.94 | CAPN1 (0.51) | CAPN1ALDH1A1MAPTCTSS | |
| SCHEMBL21854108 | 0.93 | CAPN1 (0.52) | CAPN1ALDH1A1MAPTCTSS | |
| SCHEMBL20027684 | 0.93 | CAPN1 (0.52) | CAPN1ALDH1A1MAPTCTSS | |
| SCHEMBL21854041 | 0.92 | MAPT (0.52) | CAPN1ALDH1A1MAPTCTSS | |
| SCHEMBL20027971 | 0.92 | MAPT (0.52) | CAPN1ALDH1A1MAPTCTSS | |
| SCHEMBL21854307 | 0.92 | CAPN1 (0.49) | CAPN1ALDH1A1MAPTCTSSKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-20210113560-A1 | METHOD OF TREATING FIBROTIC DISEASE | BLADE THERAPEUTICS INC (US) | 2021-04-22 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | CAPN1 3/4885ALDH1A1 4193/4885MAPT 562/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | CAPN1 4/4885ALDH1A1 4421/4885MAPT 330/4885 |
| US-20210113560-A1 | METHOD OF TREATING FIBROTIC DISEASE | CAPN9, CAPNS1, CAPN1 | CAPN1 3/4885ALDH1A1 1657/4885MAPT 2905/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | CAPN1 3/4885ALDH1A1 4193/4885MAPT 562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.