Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PPID | Q08752 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20027767 | 0.87 | TSHR (0.53) | TSHRSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL7788580 | 0.85 | TSHR (0.67) | TSHRSMN1; SMN2BRD4KDM4ECYP1A2 | |
| SCHEMBL18630525 | 0.82 | BRD4 (0.53) | BRD4CYP3A4NAMPT | |
| SCHEMBL10242983 | 0.81 | TSHR (0.58) | TSHRSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL28540163 | 0.81 | TSHR (0.61) | TSHRSMN1; SMN2BRD4KDM4ECYP1A2 | |
| SCHEMBL20457819 | 0.81 | TSHR (0.66) | TSHRSMN1; SMN2BRD4KDM4ECYP1A2 | |
| SCHEMBL13181425 | 0.81 | TSHR (0.61) | TSHRSMN1; SMN2BRD4KDM4ECYP1A2 | |
| SCHEMBL6331303 | 0.78 | TSHR (0.67) | TSHRSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL5836449 | 0.78 | TSHR (0.58) | TSHRSMN1; SMN2BRD4KDM4ECYP1A2 | |
| SCHEMBL25772234 | 0.78 | TSHR (0.58) | TSHRSMN1; SMN2BRD4KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |