Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.46 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20028889 | 0.85 | USP30 (0.47) | USP30SCD5PIK3CAGPR119RORC | |
| SCHEMBL20028690 | 0.85 | USP30 (0.47) | USP30SCD5PIK3CAGPR119RORC | |
| SCHEMBL20028842 | 0.81 | USP30 (0.68) | USP30SCD5GPR119 | |
| SCHEMBL28779051 | 0.80 | USP30 (0.42) | USP30CYP11B2PIK3R1PIK3CA | |
| SCHEMBL20028899 | 0.76 | USP30 (0.41) | USP30CYP11B2PIK3R1PIK3CARORC | |
| SCHEMBL29679555 | 0.75 | USP30 (0.46) | USP30SCD5GPR119RORC | |
| SCHEMBL20028867 | 0.75 | USP30 (0.46) | USP30SCD5GPR119RORC | |
| SCHEMBL20028870 | 0.75 | USP30 (0.46) | USP30SCD5GPR119RORC | |
| SCHEMBL10163290 | 0.74 | USP30 (0.42) | USP30SCD5CYP11B2PIK3R1PIK3CA | |
| SCHEMBL20028693 | 0.73 | USP30 (0.41) | USP30SCD5PIK3CAGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109790148-B | Cyano-substituted heterocycles having USP30 inhibitor activity | 特殊治疗有限公司 | 2022-06-07 | — | — | CN | disclosed |
| EP-3519397-B1 | CYANO-SUBTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LTD (GB) | 2021-05-19 | — | — | EP | disclosed |
| WO-2018060691-A1 | CYANO-SUBTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2018-04-05 | — | — | WO | disclosed |