Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 17/20 | 0.71 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL18038250 | 0.95 | ROCK1 (0.65) | ROCK1ROCK2 | |
| SCHEMBL18056522 | 0.86 | ROCK1 (0.77) | ROCK1ROCK2 | |
| SCHEMBL18056557 | 0.84 | ROCK1 (0.74) | ROCK1ROCK2 | |
| SCHEMBL18038163 | 0.83 | ROCK1 (0.79) | ROCK1ROCK2 | |
| SCHEMBL18056355 | 0.82 | ROCK1 (0.73) | ROCK1ROCK2 | |
| SCHEMBL18056407 | 0.82 | ROCK1 (0.69) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038296 | 0.81 | ROCK1 (0.70) | ROCK1ROCK2 | |
| SCHEMBL18056553 | 0.81 | ROCK1 (0.72) | ROCK1ROCK2 | |
| SCHEMBL18038229 | 0.80 | ROCK1 (0.76) | ROCK1ROCK2 | |
| SCHEMBL18056616 | 0.80 | ROCK1 (0.69) | ROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093978-A1 | INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093978-A1 | INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE | ROCK1, ROCK2, CIT | ROCK1 1/4885ROCK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.