Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14969670 | 1.00 | NR1H2 (0.48) | NR1H2NAMPTUSP2SMN1; SMN2MEN1 | |
| SCHEMBL23555640 | 1.00 | NR1H2 (0.48) | NR1H2NAMPTUSP2SMN1; SMN2MEN1 | |
| SCHEMBL20463845 | 0.92 | NR1H2 (0.46) | NR1H2NAMPTUSP2SMN1; SMN2MEN1 | |
| SCHEMBL15946892 | 0.89 | NR1H2 (0.44) | NR1H2NAMPTUSP2SMN1; SMN2MEN1 | |
| SCHEMBL20463843 | 0.86 | NR1H2 (0.43) | NR1H2NAMPTUSP2SMN1; SMN2MEN1 | |
| SCHEMBL8488452 | 0.84 | NR1H2 (0.49) | NR1H2NAMPTUSP2SMN1; SMN2MEN1 | |
| SCHEMBL8486841 | 0.84 | NR1H2 (0.49) | NR1H2NAMPTUSP2SMN1; SMN2MEN1 | |
| SCHEMBL9189316 | 0.84 | NR1H2 (0.49) | NR1H2NAMPTUSP2SMN1; SMN2MEN1 | |
| SCHEMBL2384096 | 0.80 | NR1H2 (0.54) | NR1H2NAMPTUSP2SMN1; SMN2MEN1 | |
| SCHEMBL31339919 | 0.78 | NR1H2 (0.49) | NR1H2NAMPTUSP2SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519412-B1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LTD (GB) | 2021-12-01 | — | — | EP | disclosed |
| WO-2018060742-A1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2018-04-05 | — | — | WO | disclosed |