SCHEMBL20031574

SCHEMBL20031574

COC(=O)c1csc(N2CC3CCCC3C2)n1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 4/20 0.55
CRBN Q96SW2 1/20 0.47
HCRTR1 O43613 1/20 0.44
HCRTR2 O43614 1/20 0.44
MAOA P21397 1/20 0.39
ACHE P22303 1/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
POLB P06746 1/20 0.38
HPGD P15428 1/20 0.38
BLM P54132 1/20 0.38
ESR2 Q92731 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
MAPT P10636 1/20 0.37
RAB9A P51151 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
ACKR3 P25106 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20031104 0.83 LDHA (0.47) HRH3ALDH1A1SMN1; SMN2
SCHEMBL15357058 0.83 HRH3 (0.50) HRH3CRBNHCRTR1HCRTR2MAOA
SCHEMBL2554680 0.81 HRH3 (0.58) HRH3CRBNHCRTR1HCRTR2MAOA
SCHEMBL2550688 0.81 CRBN (0.50) HRH3CRBNHCRTR1HCRTR2MAOA
SCHEMBL2549387 0.80 HRH3 (0.57) HRH3CRBNMAOAACHEMEN1
SCHEMBL13161917 0.80 HRH3 (0.55) HRH3CRBNHCRTR1HCRTR2MAOA
SCHEMBL13163985 0.79 HRH3 (0.49) HRH3CRBNHCRTR1HCRTR2MAOA
SCHEMBL13161921 0.79 HRH3 (0.60) HRH3CRBNHCRTR1HCRTR2MEN1
SCHEMBL13162809 0.77 HRH3 (0.64) HRH3CRBNHCRTR1HCRTR2MEN1
SCHEMBL2555446 0.76 HRH3 (0.54) HRH3CRBNHCRTR1HCRTR2MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018059314-A1 AZABICYCLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2018-04-05 WO disclosed