Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20032166 | 0.86 | MAPT (0.38) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL21508073 | 0.84 | MAPT (0.42) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL16574060 | 0.84 | MAPT (0.44) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL21508079 | 0.82 | RAB9A (0.45) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL21508040 | 0.82 | MAPT (0.45) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL21366596 | 0.81 | GRM5 (0.40) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL17656956 | 0.81 | MAPT (0.44) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL21508001 | 0.79 | MAPT (0.42) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL17656957 | 0.78 | MAPT (0.41) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL18713769 | 0.76 | MAPT (0.39) | MAPTRAB9AKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041842-B1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS INC (US) | 2019-10-23 | — | — | EP | disclosed |
| WO-2018060949-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR USE IN THE TREATMENT OF LIVER DISEASES | ROIVANT SCIENCES GMBH (CH) | 2018-04-05 | — | — | WO | disclosed |