Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.80 |
| ▸ | PPARD | Q03181 | 1/20 | 0.80 |
| ▸ | PPARA | Q07869 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL814753 | 0.90 | PPARA (0.78) | PPARGPPARDPPARAMEN1ALDH1A1 | |
| SCHEMBL12186109 | 0.89 | PPARG (0.77) | PPARGPPARDPPARAMEN1ALDH1A1 | |
| Elafibranor SCHEMBL23143340 | 0.89 | PPARA (1.00) | PPARGPPARDPPARAMEN1ALDH1A1 | |
| Elafibranor SCHEMBL16552997 | 0.89 | PPARA (1.00) | PPARGPPARDPPARAMEN1ALDH1A1 | |
| SCHEMBL20110591 | 0.89 | PPARA (0.83) | PPARGPPARDPPARAMEN1ALDH1A1 | |
| Elafibranor SCHEMBL815512 | 0.89 | PPARA (1.00) | PPARGPPARDPPARAMEN1ALDH1A1 | |
| SCHEMBL814777 | 0.88 | PPARA (0.75) | PPARGPPARDPPARAMEN1ALDH1A1 | |
| SCHEMBL20932824 | 0.87 | PPARG (0.80) | PPARGPPARDPPARAMEN1ALDH1A1 | |
| SCHEMBL21351480 | 0.87 | PPARA (0.83) | PPARGPPARDPPARAMEN1ALDH1A1 | |
| SCHEMBL21758868 | 0.86 | PPARA (0.71) | PPARGPPARDPPARAMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3518912-B1 | DUAL-ACTION ELAFIBRANOR METFORMIN SALT FOR TREATING OBESITY ASSOCIATED WITH NON-ALCOHOLIC STEATOHEPATITIS (NASH) AND HYPERTRIGLYCERIDAEMIA | NASHPHARM (FR) | 2020-12-30 | — | — | EP | disclosed |
| WO-2018060373-A1 | DUAL-ACTION ELAFIBRANOR METFORMIN SALT FOR TREATING OBESITY ASSOCIATED WITH NON-ALCOHOLIC STEATOHEPATITIS (NASH) AND HYPERTRIGLYCERIDAEMIA | NASHPHARM (FR) | 2018-04-05 | — | — | WO | disclosed |