Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.71 |
| ▸ | PPARG | P37231 | 1/20 | 0.71 |
| ▸ | PPARD | Q03181 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12186109 | 0.90 | PPARG (0.77) | PPARAPPARGPPARDLMNAMAPT | |
| SCHEMBL20032087 | 0.86 | PPARG (0.80) | PPARAPPARGPPARDLMNAMAPT | |
| SCHEMBL814777 | 0.85 | PPARA (0.75) | PPARAPPARGPPARDLMNAMAPT | |
| SCHEMBL814753 | 0.85 | PPARA (0.78) | PPARAPPARGPPARDLMNAMAPT | |
| SCHEMBL21351480 | 0.83 | PPARA (0.83) | PPARAPPARGPPARDLMNAMAPT | |
| Elafibranor SCHEMBL23143340 | 0.83 | PPARA (1.00) | PPARAPPARGPPARDLMNAMAPT | |
| Elafibranor SCHEMBL815512 | 0.83 | PPARA (1.00) | PPARAPPARGPPARDLMNAMAPT | |
| Elafibranor SCHEMBL16552997 | 0.83 | PPARA (1.00) | PPARAPPARGPPARDLMNAMAPT | |
| SCHEMBL20110591 | 0.83 | PPARA (0.83) | PPARAPPARGPPARDLMNAMAPT | |
| SCHEMBL20932824 | 0.82 | PPARG (0.80) | PPARAPPARGPPARDLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020039297-A1 | NOVEL COMPOUNDS AND THEIR USE IN PREPARATION OF ELAFIBRANOR AND PHARMACEUTICAL ACCEPTABLE SALTS THEREOF | MANKIND PHARMA LTD. (IN) | 2020-02-27 | — | — | WO | disclosed |