Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | KIF5B | P33176 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.41 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.41 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29492471 | 0.88 | PDGFRB (0.55) | SRCTGFBR1PDGFRAPDGFRBEGFR | |
| SCHEMBL165285 | 0.88 | PDGFRB (0.55) | SRCTGFBR1PDGFRAPDGFRBEGFR | |
| SCHEMBL23597420 | 0.86 | EGFR (0.47) | SRCPDGFRAPDGFRBKDRRET | |
| Hydrochloric Acid SCHEMBL4463414 | 0.86 | PDGFRB (0.54) | SRCTGFBR1PDGFRAPDGFRBEGFR | |
| SCHEMBL30498652 | 0.86 | EGFR (0.47) | SRCPDGFRAPDGFRBKDRRET | |
| SCHEMBL28439891 | 0.83 | EGFR (0.47) | SRCTGFBR1PDGFRAPDGFRBKDR | |
| SCHEMBL15960727 | 0.82 | TLR8 (0.45) | SRCTGFBR1TLR8PDGFRAPDGFRB | |
| SCHEMBL11985290 | 0.82 | PDGFRB (0.43) | SRCTGFBR1PDGFRAPDGFRBEGFR | |
| SCHEMBL14756275 | 0.82 | EGFR (0.45) | SRCTLR8PDGFRAPDGFRBKDR | |
| SCHEMBL12444115 | 0.80 | TLR8 (0.47) | TLR8PDGFRAPDGFRBRETRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180099962-A1 | NAPHTHYRIDINE COMPOUNDS, MEDICAL COMBINATIONS AND USE THEREOF | NANJING NATINEFY PHARMATECH CO., LTD. (CN) | 2018-04-12 | — | — | US | disclosed |
| US-9938274-B1 | Naphthyridine compounds, medical combinations and use thereof | NANJING NATINEFY PHARMATECH CO., LTD. (CN) | 2018-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180099962-A1 | NAPHTHYRIDINE COMPOUNDS, MEDICAL COMBINATIONS AND USE THEREOF | NPM1, NEK4, NME1 | SRC 697/4885TGFBR1 4034/4885TLR8 2238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.