Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | KIF5B | P33176 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 2/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.43 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.43 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.43 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23597420 | 1.00 | EGFR (0.47) | EGFRPDGFRAPDGFRBFGFR2RET | |
| SCHEMBL28439891 | 0.93 | EGFR (0.47) | EGFRPDGFRAPDGFRBRETKDR | |
| SCHEMBL29492471 | 0.91 | PDGFRB (0.55) | EGFRPDGFRAPDGFRBFGFR2GAK | |
| SCHEMBL165285 | 0.91 | PDGFRB (0.55) | EGFRPDGFRAPDGFRBFGFR2GAK | |
| SCHEMBL10296329 | 0.91 | PDGFRB (0.55) | EGFRPDGFRAPDGFRBFGFR2SRC | |
| Hydrochloric Acid SCHEMBL4463414 | 0.89 | PDGFRB (0.54) | EGFRPDGFRAPDGFRBFGFR2GAK | |
| SCHEMBL10026410 | 0.86 | SRC (0.46) | EGFRPDGFRAPDGFRBFGFR2RET | |
| SCHEMBL20032547 | 0.86 | SRC (0.46) | EGFRPDGFRAPDGFRBFGFR2RET | |
| SCHEMBL11985290 | 0.85 | PDGFRB (0.43) | EGFRPDGFRAPDGFRBFGFR2GAK | |
| SCHEMBL14756275 | 0.85 | EGFR (0.45) | EGFRPDGFRAPDGFRBRETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116444489-A | Quinoline derivative, preparation method and application thereof | 正大天晴药业集团股份有限公司 | 2023-07-18 | — | — | CN | disclosed |