Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.58 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.54 |
| ▸ | ALPG | P10696 | 2/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31439600 | 0.82 | PDK1 (0.58) | PDK1TDP1ALDH1A1LMNAKDM4E | |
| SCHEMBL31439470 | 0.82 | CYP19A1 (0.57) | CYP19A1ALPGALPITDP1PLAA | |
| SCHEMBL18232140 | 0.82 | CYP19A1 (0.57) | CYP19A1ALPGALPITDP1PLAA | |
| SCHEMBL31439550 | 0.81 | PDK1 (0.54) | PDK1TDP1ALDH1A1LMNAKDM4E | |
| SCHEMBL8144459 | 0.80 | CYP19A1 (0.69) | CYP19A1ALPGALPITDP1PLAA | |
| SCHEMBL16914849 | 0.77 | CYP19A1 (0.62) | CYP19A1ALPGALPITDP1PLAA | |
| SCHEMBL16924922 | 0.77 | PDK1 (0.70) | PDK1TDP1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL16924930 | 0.77 | PDK1 (0.66) | PDK1TDP1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL18232134 | 0.76 | PDK1 (0.56) | PDK1TDP1ALDH1A1LMNAKDM4E | |
| SCHEMBL20033128 | 0.75 | PDK1 (0.55) | PDK1L3MBTL1ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025015167-A2 | ERASTIN KETONE ANALOGS AND USES THEREOF | EXARTA THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |
| US-9938245-B2 | Carbonyl erastin analogs and their use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-04-10 | — | — | US | disclosed |
| US-9938245-B2 | Carbonyl erastin analogs and their use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-04-10 | — | — | US | disclosed |