Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707182 | 0.89 | HPGD (0.46) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL12221860 | 0.88 | HPGD (0.48) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL564869 | 0.87 | HPGD (0.44) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL10031015 | 0.86 | HPGD (0.51) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL18510178 | 0.86 | HPGD (0.51) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14655047 | 0.84 | HPGD (0.47) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL13225862 | 0.84 | HPGD (0.55) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL19817596 | 0.84 | HPGD (0.52) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL18519252 | 0.81 | HPGD (0.53) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14857367 | 0.81 | HPGD (0.53) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9937268-B2 | Anti-DLL3 antibody drug conjugates and methods of use | ABBVIE STEMCENTRX LLC (US) | 2018-04-10 | — | — | US | disclosed |