Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 5/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 9/20 | 0.34 |
| ▸ | STK4 | Q13043 | 1/20 | 0.33 |
| ▸ | STK3 | Q13188 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20034118 | 0.95 | BRD4 (0.38) | BRD4ULK1PIK3CGKITCCNB2 | |
| SCHEMBL20034111 | 0.95 | BRD4 (0.40) | BRD4ULK1PIK3CGKITSTK4 | |
| SCHEMBL20034094 | 0.87 | ULK1 (0.40) | BRD4ULK1PIK3CGKIT | |
| SCHEMBL20034104 | 0.83 | BRD4 (0.41) | BRD4ULK1PIK3CGKITCCNB2 | |
| SCHEMBL20034100 | 0.82 | BRD4 (0.36) | BRD4ULK1PIK3CGKITCCNB2 | |
| SCHEMBL20034086 | 0.81 | BRD4 (0.40) | BRD4ULK1PIK3CGKITCCNB2 | |
| SCHEMBL20034120 | 0.80 | BRD4 (0.38) | BRD4ULK1PIK3CGKITCSF1R | |
| SCHEMBL20034117 | 0.80 | BRD4 (0.39) | BRD4ULK1PIK3CGKITCSF1R | |
| SCHEMBL18918898 | 0.79 | ULK1 (0.45) | BRD4ULK1PIK3CGKIT | |
| SCHEMBL20034134 | 0.79 | BRD4 (0.41) | BRD4ULK1PIK3CGKITSTK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938273-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2018-04-10 | — | — | US | disclosed |