Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 15/20 | 1.00 |
| ▸ | CFTR | P13569 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | GUSB | P08236 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14987201 | 0.96 | GLS (1.00) | GLSCFTR | |
| SCHEMBL15042456 | 0.94 | GLS (1.00) | GLSCFTRMEN1POLBCYP2C19 | |
| SCHEMBL17193304 | 0.92 | GLS (0.91) | GLSCFTRMEN1POLBCYP2C19 | |
| SCHEMBL14987152 | 0.86 | GLS (1.00) | GLSCFTR | |
| SCHEMBL15043814 | 0.84 | GLS (1.00) | GLSCFTRMEN1POLBCYP2C19 | |
| SCHEMBL15042328 | 0.84 | GLS (1.00) | GLS | |
| SCHEMBL19061853 | 0.83 | CFTR (1.00) | GLSCFTRMEN1POLBKMT2A | |
| SCHEMBL16887460 | 0.81 | GLS (0.79) | GLS | |
| SCHEMBL15042380 | 0.81 | GLS (1.00) | GLSCFTRMEN1POLBCYP2C19 | |
| SCHEMBL14987489 | 0.80 | GLS (1.00) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938267-B2 | Heterocyclic inhibitors of glutaminase | CALITHERA BIOSCIENCES, INC. (US) | 2018-04-10 | — | — | US | disclosed |