⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004482 | 0.70 | — | — | |
| SCHEMBL70020 | 0.67 | — | — | |
| SCHEMBL18925341 | 0.65 | — | — | |
| SCHEMBL2004800 | 0.65 | — | — | |
| SCHEMBL659548 | 0.62 | — | — | |
| SCHEMBL1997298 | 0.61 | — | — | |
| SCHEMBL3611106 | 0.58 | — | — | |
| SCHEMBL2000684 | 0.56 | — | — | |
| SCHEMBL3906666 | 0.56 | KDM4E (0.39) | — | |
| SCHEMBL3897125 | 0.56 | CLK1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10383874-B2 | Arylquinazolines | MERK PATENT GMBH (DE) | 2019-08-20 | — | — | US | claimed |
| US-20190142833-A1 | ARYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2019-05-16 | — | — | US | claimed |
| US-10172859-B2 | Arylquinazolines | MERCK PATENT GMBH (DE) | 2019-01-08 | — | — | US | claimed |
| EP-2994467-B1 | ARYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2018-08-01 | — | — | EP | claimed |
| US-20170290836-A1 | ARYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2017-10-12 | — | — | US | claimed |
| US-20160083401-A1 | ARYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | US | claimed |
| EP-2994467-A1 | ARYLQUINAZOLINES | Merck Patent GmbH (DE) | 2016-03-16 | — | — | EP | claimed |
| WO-2014183850-A1 | ARYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2014-11-20 | — | — | WO | claimed |
| EP-0848000-B1 | Pharmaceutical pyridine derivatives, processes for preparing the same and intermediates therefor | TANABE SEIYAKU CO (JP) | 2002-06-12 | — | — | EP | claimed |
| JP-2002506073-A | — | — | 2002-02-26 | — | — | JP | claimed |
| US-20020019412-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2002-02-14 | — | — | US | claimed |
| EP-1062218-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | claimed |
| US-5965730-A | SELECTIVE PHOSPHODIESTEARASE IV INHIBITOR HAVING BRONCHODIALATION AND ANTI-INFLAMMATORY ACTIVITY; PROPHYLAXIS AND TREATMENT OF ASTHMA | TANABE SEIYAKU CO., LTD. (JP) | 1999-10-12 | — | — | US | claimed |
| WO-1999046268-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | claimed |
| EP-0848000-A1 | Pharmaceutical pyridine derivatives, processes for preparing the same and intermediates therefor | TANABE SEIYAKU CO., LTD. (JP) | 1998-06-17 | — | — | EP | claimed |
| US-20220117970-A1 | ARYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2022-04-21 | — | — | US | disclosed |
| US-11065253-B2 | Arylquinazolines | MERCK PATENT GMBH (DE) | 2021-07-20 | — | — | US | disclosed |
| US-5965730-A | SELECTIVE PHOSPHODIESTEARASE IV INHIBITOR HAVING BRONCHODIALATION AND ANTI-INFLAMMATORY ACTIVITY; PROPHYLAXIS AND TREATMENT OF ASTHMA | TANABE SEIYAKU CO., LTD. (JP) | 1999-10-12 | — | — | US | disclosed |
| WO-1999046268-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |
| EP-0848000-A1 | Pharmaceutical pyridine derivatives, processes for preparing the same and intermediates therefor | TANABE SEIYAKU CO., LTD. (JP) | 1998-06-17 | — | — | EP | disclosed |