Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | GNAI3 | P08754 | 9/20 | 0.62 |
| ▸ | GNAI1 | P63096 | 9/20 | 0.62 |
| ▸ | GNAO1 | P09471 | 8/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663914 | 0.93 | MEN1 (0.81) | MEN1KMT2APOLBMAPTGNAI3 | |
| SCHEMBL7533923 | 0.90 | MEN1 (0.88) | MEN1KMT2APOLBMAPTGNAI3 | |
| SCHEMBL14879717 | 0.90 | MEN1 (0.88) | MEN1KMT2APOLBMAPTGNAI3 | |
| SCHEMBL8423209 | 0.90 | MEN1 (0.88) | MEN1KMT2APOLBMAPTGNAI3 | |
| SCHEMBL3365303 | 0.90 | NPC1 (0.76) | MEN1KMT2APOLBMAPTGNAI3 | |
| SCHEMBL14879738 | 0.90 | NPC1 (0.76) | MEN1KMT2APOLBMAPTGNAI3 | |
| SCHEMBL25934640 | 0.88 | NPC1 (0.79) | MEN1KMT2APOLBMAPTGNAI3 | |
| SCHEMBL10274495 | 0.86 | MEN1 (0.65) | MEN1KMT2APOLBMAPTGNAI3 | |
| SCHEMBL19528315 | 0.86 | MEN1 (0.65) | MEN1KMT2APOLBMAPTGNAI3 | |
| SCHEMBL17739977 | 0.85 | NPC1 (0.59) | MEN1KMT2APOLBMAPTGNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938323-B2 | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase | NOVARTIS AG (CH) | 2018-04-10 | — | — | US | disclosed |