Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.81 |
| ▸ | POLB | P06746 | 1/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.81 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | GNAI3 | P08754 | 9/20 | 0.53 |
| ▸ | GNAI1 | P63096 | 9/20 | 0.53 |
| ▸ | GNAO1 | P09471 | 8/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20034969 | 0.93 | MEN1 (0.71) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL29191667 | 0.90 | KMT2A (1.00) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL10274495 | 0.89 | MEN1 (0.65) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL9062091 | 0.89 | NPC1 (0.81) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL19528315 | 0.89 | MEN1 (0.65) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL24393443 | 0.87 | MEN1 (0.88) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL12895626 | 0.85 | MEN1 (0.69) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL13663708 | 0.84 | NPC1 (0.62) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL21945132 | 0.84 | NPC1 (0.68) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL25934640 | 0.84 | NPC1 (0.79) | MEN1KMT2APOLBMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231657-A1 | BIARYL SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY MODULATORS | Abbott Laboratories (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009067579-A1 | BIARYL SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY MODULATORS | ABBOTT LABORATORIES (US) | 2009-05-28 | — | — | WO | disclosed |