Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.63 |
| ▸ | HCK | P08631 | 16/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 16/20 | 0.63 |
| ▸ | SRC | P12931 | 3/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 2/20 | 0.50 |
| ▸ | CIT | O14578 | 1/20 | 0.50 |
| ▸ | MUSK | O15146 | 1/20 | 0.50 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | STK10 | O94804 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.50 |
| ▸ | PRKCB | P05771 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20060666 | 0.90 | MAPK14 (0.60) | MAPK14HCKMAPK12SRCMAPK13 | |
| SCHEMBL20036763 | 0.90 | MAPK14 (0.67) | MAPK14HCKMAPK12SRCMAPK13 | |
| SCHEMBL20036766 | 0.89 | MAPK14 (0.79) | MAPK14HCKMAPK12SRCMAPK13 | |
| SCHEMBL20036756 | 0.89 | MAPK14 (0.58) | MAPK14HCKMAPK12SRCMAPK13 | |
| SCHEMBL14701111 | 0.89 | MAPK14 (0.77) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL2408681 | 0.88 | MAPK14 (0.80) | MAPK14HCKMAPK12SRCMAPK13 | |
| SCHEMBL20036726 | 0.88 | MAPK14 (0.67) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL17008530 | 0.87 | MAPK14 (0.56) | MAPK14HCKMAPK12SRCMAPK13 | |
| SCHEMBL20036765 | 0.87 | MAPK14 (0.66) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL20036739 | 0.86 | MAPK14 (0.78) | MAPK14HCKMAPK12SRCGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509595-B1 | INHIBITORS OF HEMOPOIETIC CELL KINASE (P59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION | RESPIVERT LTD (GB) | 2018-04-11 | — | — | EP | disclosed |