Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.60 |
| ▸ | SRC | P12931 | 11/20 | 0.58 |
| ▸ | GSK3A | P49840 | 9/20 | 0.58 |
| ▸ | HCK | P08631 | 8/20 | 0.58 |
| ▸ | SYK | P43405 | 7/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.50 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | MUSK | O15146 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20036715 | 0.90 | MAPK14 (0.63) | MAPK14MAPK12SRCHCKGSK3B | |
| SCHEMBL20060663 | 0.90 | MAPK14 (0.60) | MAPK14MAPK12SRCGSK3AHCK | |
| SCHEMBL20060670 | 0.89 | MAPK14 (0.65) | MAPK14MAPK12SRCGSK3AHCK | |
| SCHEMBL20060580 | 0.89 | MAPK14 (0.62) | MAPK14MAPK12SRCGSK3AHCK | |
| SCHEMBL12288114 | 0.89 | MAPK14 (0.75) | MAPK14MAPK12SRCGSK3AHCK | |
| SCHEMBL20060691 | 0.88 | MAPK14 (0.65) | MAPK14MAPK12SRCGSK3AHCK | |
| SCHEMBL20060696 | 0.88 | MAPK14 (0.65) | MAPK14MAPK12SRCGSK3AHCK | |
| SCHEMBL20060602 | 0.88 | MAPK14 (0.60) | MAPK14MAPK12SRCGSK3AHCK | |
| SCHEMBL12540644 | 0.88 | MAPK14 (0.78) | MAPK14MAPK12SRCGSK3AHCK | |
| SCHEMBL20060700 | 0.87 | MAPK14 (0.64) | MAPK14MAPK12SRCGSK3AHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582433-B1 | UREIDO-PYRAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF RHINOVIRUS INFECTIONS | RESPIVERT LTD (GB) | 2018-04-18 | — | — | EP | disclosed |