Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK6 | Q92876 | 8/20 | 0.77 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.77 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.77 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037270 | 0.87 | KLK6 (1.00) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037224 | 0.85 | KLK6 (0.82) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037112 | 0.85 | KLK6 (0.62) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037137 | 0.82 | KLK6 (0.86) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037005 | 0.82 | KLK6 (0.89) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037221 | 0.80 | KLK6 (0.86) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037079 | 0.80 | KLK6 (0.83) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037117 | 0.79 | KLK6 (0.81) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037090 | 0.79 | KLK6 (0.75) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037069 | 0.79 | KLK6 (0.69) | KLK6PRSS1PRSS2PRSS3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018065607-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2018-04-12 | — | — | WO | disclosed |
| EP-3305781-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN-RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum (DE) | 2018-04-11 | — | — | EP | disclosed |