Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK6 | Q92876 | 7/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.62 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.62 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037077 | 0.87 | KLK6 (0.72) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037033 | 0.85 | KLK6 (0.77) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037129 | 0.84 | KLK6 (0.63) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037130 | 0.84 | KLK6 (0.65) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037285 | 0.80 | KLK6 (0.65) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037090 | 0.80 | KLK6 (0.75) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037160 | 0.79 | KLK6 (0.61) | KLK6PRSS1PRSS2PRSS3RAB9A | |
| SCHEMBL20037131 | 0.77 | KLK6 (0.65) | KLK6PRSS1PRSS2PRSS3RAB9A | |
| SCHEMBL20037270 | 0.77 | KLK6 (1.00) | KLK6PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL20037081 | 0.76 | KLK6 (0.72) | KLK6PRSS1PRSS2PRSS3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018065607-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2018-04-12 | — | — | WO | disclosed |
| EP-3305781-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN-RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum (DE) | 2018-04-11 | — | — | EP | disclosed |