Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | DRD3 | P35462 | 4/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 9/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.36 |
| ▸ | RICTOR | Q6R327 | 6/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.36 |
| ▸ | MAPKAP1 | Q9BPZ7 | 6/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037654 | 1.00 | DRD2 (0.48) | DRD2DRD3PRKACAPRKACGPRKACB | |
| SCHEMBL3399522 | 0.83 | PRKACA (0.47) | PRKACAPRKACGPRKACBATRACVR1 | |
| SCHEMBL27392495 | 0.81 | PRKACA (0.38) | DRD2DRD3PRKACAPRKACGPRKACB | |
| SCHEMBL20038364 | 0.81 | PRKACA (0.38) | DRD2DRD3PRKACAPRKACGPRKACB | |
| SCHEMBL27392494 | 0.81 | PRKACA (0.38) | DRD2DRD3PRKACAPRKACGPRKACB | |
| SCHEMBL18291309 | 0.81 | ACVR1 (0.41) | DRD2DRD3PRKACAPRKACGPRKACB | |
| SCHEMBL20038413 | 0.81 | ACVR1 (0.41) | DRD2DRD3PRKACAPRKACGPRKACB | |
| SCHEMBL30920981 | 0.81 | PRKACA (0.38) | DRD2DRD3PRKACAPRKACGPRKACB | |
| SCHEMBL24540899 | 0.78 | NOTUM (0.40) | PRKACAPRKACGPRKACBATRACVR1 | |
| SCHEMBL29761558 | 0.78 | NOTUM (0.40) | PRKACAPRKACGPRKACBATRACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |