Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 6/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037485 | 1.00 | PTPN11 (0.37) | PTPN11HRH4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL18291191 | 0.85 | PTPN11 (0.39) | PTPN11CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL20936748 | 0.84 | CHRNB2 (0.39) | HRH4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL18290987 | 0.84 | PTPN11 (0.36) | PTPN11HRH4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20037483 | 0.84 | PIK3CA (0.37) | HRH4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL20249335 | 0.80 | HRH4 (0.44) | PTPN11HRH4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20249333 | 0.80 | HRH4 (0.44) | PTPN11HRH4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20037484 | 0.80 | NMT1 (0.37) | HRH4HRH3 | |
| SCHEMBL18291518 | 0.80 | MAP4K4 (0.37) | HRH4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL18291073 | 0.80 | HRH4 (0.36) | HRH4CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |