Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 6/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20038205 | 0.87 | DRD3 (0.41) | HRH3DRD3KCNH2CACNA2D1SLC6A2 | |
| SCHEMBL18291315 | 0.86 | DRD3 (0.41) | HRH3DRD3KCNH2CACNA2D1SLC6A2 | |
| SCHEMBL20038203 | 0.85 | HRH3 (0.44) | HRH3DRD3KCNH2CACNA2D1SLC6A2 | |
| SCHEMBL20249339 | 0.83 | HRH3 (0.43) | HRH3CACNA2D1SLC6A2AKR1C3KDM4E | |
| SCHEMBL20037546 | 0.80 | DRD3 (0.45) | DRD3KCNH2ELANEMAPT | |
| SCHEMBL1727049 | 0.79 | AKR1C3 (0.52) | HRH3DRD3KCNH2AKR1C3KDM4E | |
| SCHEMBL20038238 | 0.78 | DRD3 (0.43) | HRH3DRD3KCNH2ELANEAKR1C3 | |
| SCHEMBL255160 | 0.78 | AKR1C3 (0.51) | HRH3DRD3KCNH2ELANEAKR1C3 | |
| SCHEMBL15492562 | 0.77 | KDM4E (0.54) | HRH3KCNH2KDM4EALDH1A1MAPT | |
| SCHEMBL8356124 | 0.77 | AKR1C3 (0.50) | HRH3DRD3KCNH2ELANEAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |