Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20255186 | 0.82 | NMT1 (0.37) | HRH4HRH3NMT1 | |
| SCHEMBL20038177 | 0.82 | NMT1 (0.37) | HRH4NMT1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20037484 | 0.82 | NMT1 (0.37) | HRH4HRH3NMT1 | |
| SCHEMBL20249316 | 0.80 | HRH4 (0.40) | HRH4HRH3NMT1CHRNB2CHRNB4 | |
| SCHEMBL20249337 | 0.80 | HRH4 (0.40) | HRH4HRH3NMT1CHRNB2CHRNB4 | |
| SCHEMBL22006820 | 0.73 | NPC1 (0.50) | HRH3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13467136 | 0.73 | MAP4K4 (0.46) | HRH4HRH3 | |
| SCHEMBL20046660 | 0.72 | LMNA (0.37) | HRH4HRH3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20255432 | 0.71 | HRH4 (0.39) | HRH4HRH3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16131128 | 0.71 | HRH3 (0.42) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |