Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 3/20 | 0.32 |
| ▸ | GSK3B | P49841 | 3/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291187 | 0.89 | DRD3 (0.46) | DRD3KCNH2ACVR1ELANEPIK3CA | |
| SCHEMBL20038204 | 0.87 | PIK3CA (0.34) | DRD3KCNH2ACVR1PIK3CAMTOR | |
| SCHEMBL20249341 | 0.87 | HTT (0.35) | DRD3KCNH2ACVR1PIK3CAMTOR | |
| SCHEMBL20038327 | 0.82 | DRD3 (0.47) | DRD3KCNH2ELANEPIK3CAMTOR | |
| SCHEMBL20038238 | 0.81 | DRD3 (0.43) | DRD3KCNH2ELANEP2RX7AKR1C3 | |
| SCHEMBL14930379 | 0.80 | ACVR1 (0.47) | ACVR1ELANEPIK3CAMTORCDK4 | |
| SCHEMBL20037546 | 0.80 | DRD3 (0.45) | DRD3KCNH2ELANEKMT2A | |
| SCHEMBL18291670 | 0.79 | DRD3 (0.48) | DRD3KCNH2ELANEP2RX7CHRM4 | |
| SCHEMBL20038197 | 0.76 | AR (0.36) | DRD3KCNH2ACVR1PIK3CAMTOR | |
| SCHEMBL20249326 | 0.76 | AR (0.36) | DRD3KCNH2ACVR1PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |