Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 8/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.40 |
| ▸ | OGA | O60502 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16132009 | 0.90 | MAP4K4 (0.50) | MAP4K4 | |
| SCHEMBL12557337 | 0.83 | CDK4 (0.39) | CDK4CDK6MAP4K4L3MBTL3PARP1 | |
| SCHEMBL13768873 | 0.83 | MAP4K4 (0.44) | CDK4CDK6MAP4K4L3MBTL3PARP1 | |
| SCHEMBL1977570 | 0.83 | LMNA (0.57) | LMNAHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20255243 | 0.83 | OGA (0.40) | CDK4CDK6OGAMAP4K4L3MBTL3 | |
| SCHEMBL20037694 | 0.83 | MAP4K4 (0.44) | MAP4K4 | |
| SCHEMBL20249263 | 0.81 | CDK4 (0.39) | CDK4CDK6MAP4K4L3MBTL3PARP1 | |
| SCHEMBL20255732 | 0.81 | CDK4 (0.40) | CDK4CDK6MAP4K4PARP1 | |
| SCHEMBL12653350 | 0.80 | NPC1 (0.55) | OGALMNAHTTNPC1RAB9A | |
| SCHEMBL9413153 | 0.79 | HTT (0.44) | OGALMNAHTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |