Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291484 | 0.90 | PIM1 (0.48) | PIM1PIM3PIM2DRD3KCNH2 | |
| SCHEMBL20038031 | 0.83 | PIM1 (0.39) | PIM1AKR1C3PIM3PIM2FPR1 | |
| SCHEMBL20037639 | 0.83 | AKR1C3 (0.39) | PIM1AKR1C3PIM3PIM2HRH3 | |
| SCHEMBL20249285 | 0.83 | AKR1C3 (0.39) | PIM1AKR1C3PIM3PIM2FPR1 | |
| SCHEMBL18291533 | 0.81 | PIM1 (0.41) | PIM1AKR1C3PIM3PIM2CHRNB2 | |
| SCHEMBL28830947 | 0.79 | PIM1 (0.47) | PIM1DRD3CHRNB2CHRNA4FPR1 | |
| SCHEMBL28830946 | 0.79 | PIM1 (0.47) | PIM1DRD3CHRNB2CHRNA4FPR1 | |
| SCHEMBL20255254 | 0.79 | PIM1 (0.40) | PIM1AKR1C3PIM3PIM2FPR1 | |
| SCHEMBL29819531 | 0.79 | PIM1 (0.47) | PIM1DRD3CHRNB2CHRNA4FPR1 | |
| SCHEMBL12527658 | 0.79 | PIM1 (0.47) | PIM1DRD3CHRNB2CHRNA4FPR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |