Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 13/20 | 0.76 |
| ▸ | THRB | P10828 | 13/20 | 0.76 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.76 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.76 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.76 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.76 |
| ▸ | ASPH | Q12797 | 1/20 | 0.76 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.76 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.76 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22953368 | 0.91 | THRA (0.81) | THRATHRBEGLN1BBOX1SLC6A2 | |
| SCHEMBL14672081 | 0.89 | THRA (0.84) | THRATHRBEGLN1BBOX1SLC6A2 | |
| SCHEMBL30751026 | 0.89 | THRA (0.84) | THRATHRBEGLN1BBOX1SLC6A2 | |
| SCHEMBL522601 | 0.89 | THRA (0.60) | THRATHRBEGLN1BBOX1SLC6A2 | |
| SCHEMBL23269739 | 0.89 | THRA (0.76) | THRATHRBEGLN1BBOX1SLC6A2 | |
| SCHEMBL25669452 | 0.88 | EGLN1 (0.58) | THRATHRBEGLN1BBOX1SLC6A2 | |
| Roxadustat SCHEMBL523705 | 0.87 | THRA (1.00) | THRATHRBEGLN1BBOX1SLC6A2 | |
| Roxadustat SCHEMBL29892426 | 0.87 | THRA (1.00) | THRATHRBEGLN1BBOX1SLC6A2 | |
| Roxadustat SCHEMBL29350689 | 0.87 | THRA (1.00) | THRATHRBEGLN1BBOX1SLC6A2 | |
| SCHEMBL523583 | 0.87 | EGLN1 (0.62) | THRATHRBEGLN1BBOX1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252295-A1 | PROCESS OF MAKING ROXADUSTAT | SUZHOU PENGXU PHARMATECH CO., LTD. (CN) | 2021-12-16 | — | — | WO | disclosed |
| EP-3305769-B1 | METHOD FOR PREPARATION OF (7-PHENOXY-4-HYDROXY-1-METHYL-ISOQUINOLINE-3-CARBONYL)-GLYCINE (ROXEDUSTAT) AND ITS INTERMEDIATES BASED ON SIMULTANEOUS OPENING OF OXAZOLIC RING, FISSION OF ETHER AND CREATION OF IMINE | ZENTIVA KS (CZ) | 2019-06-26 | — | — | EP | disclosed |
| EP-3305769-A1 | METHOD FOR PREPARATION OF (7-PHENOXY-4-HYDROXY-1-METHYL-ISOQUINOLINE-3-CARBONYL)-GLYCINE (ROXEDUSTAT) AND ITS INTERMEDIATES BASED ON SIMULTANEOUS OPENING OF OXAZOLIC RING, FISSION OF ETHER AND CREATION OF IMINE | Zentiva K.S. (CZ) | 2018-04-11 | — | — | EP | disclosed |