SCHEMBL20040203

SCHEMBL20040203

Cc1ccc(C2(c3ccc(C)cc3)c3cc(-c4cccs4)ccc3-c3cc4c(cc32)-c2sc3cc(-c5cccs5)sc3c2C4(c2ccc(C)cc2)c2ccc(C)cc2)cc1

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 1/20 0.36
PGR P06401 1/20 0.32
SLC6A11 P48066 1/20 0.32
KDM4E B2RXH2 2/20 0.31
ALDH1A1 P00352 2/20 0.31
HPGD P15428 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
NPC1 O15118 1/20 0.31
NFKB1 P19838 1/20 0.31
RAB9A P51151 1/20 0.31
NFKB2 Q00653 1/20 0.31
RELA Q04206 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
ADORA1 P30542 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20040204 0.86 MAOA (0.30)
SCHEMBL24060686 0.86
SCHEMBL20040148 0.86 PDK2 (0.40) PDK2PGRSLC6A11KDM4EALDH1A1
SCHEMBL20040198 0.84 PDK2 (0.48) PDK2PGRSLC6A11KDM4EALDH1A1
SCHEMBL20040229 0.82 PDK2 (0.39) PDK2PGRSLC6A11KDM4EALDH1A1
SCHEMBL20040168 0.77 MAOA (0.32) KDM4EALDH1A1HPGDNPSR1TDP1
SCHEMBL20365635 0.75 PDK2 (0.41) PDK2PGRSLC6A11KDM4EALDH1A1
SCHEMBL20040201 0.75 BTK (0.31) KDM4EALDH1A1NPC1NFKB1RAB9A
SCHEMBL21156749 0.74
SCHEMBL17244791 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3306690-A1 ORGANIC SEMICONDUCTING COMPOUNDS Merck Patent GmbH (DE) 2018-04-11 EP disclosed