Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15542604 | 0.86 | NR2E1 (0.41) | BRAFKDRIDH1MAOAGRM2 | |
| SCHEMBL15541319 | 0.85 | BRAF (0.40) | BRAFKDRIDH1GRM2NOTUM | |
| SCHEMBL15542193 | 0.75 | GRM2 (0.39) | BRAFKDRIDH1GRM2 | |
| SCHEMBL10104299 | 0.74 | KDM4E (0.46) | BRAFKDRFFAR4 | |
| SCHEMBL7434269 | 0.74 | MAOA (0.66) | MAOAMAOBGRM2 | |
| SCHEMBL14540825 | 0.72 | GRM2 (0.55) | MAOAMAOBGRM2 | |
| SCHEMBL25745795 | 0.71 | FFAR4 (0.45) | IDH1FFAR4 | |
| SCHEMBL5223171 | 0.71 | MAOA (0.40) | IDH1MAOAMAOBGRM2 | |
| SCHEMBL9805017 | 0.70 | MAOA (0.43) | BRAFKDRMAOAGRM2FFAR4 | |
| SCHEMBL9846421 | 0.70 | MAOA (0.54) | MAOAMAOBGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864289-B1 | CYCLOPROPANECARBOXAMIDO-SUBSTITUTED AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS | CB THERAPEUTICS INC (KY) | 2018-04-11 | — | — | EP | disclosed |