Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16792509 | 0.88 | KMT2A (0.46) | KMT2AMEN1KDM4ETDP1L3MBTL1 | |
| SCHEMBL20041007 | 0.85 | KDM4E (0.43) | KMT2AMEN1KDM4ELMNAHSPB1 | |
| SCHEMBL16792671 | 0.81 | KMT2A (0.67) | KMT2AMEN1KDM4EBRAFMAP4K4 | |
| SCHEMBL19676352 | 0.80 | KMT2A (0.50) | KMT2AMEN1KDM4EDGAT1HPGD | |
| SCHEMBL8460938 | 0.78 | KMT2A (0.66) | KMT2AMEN1KDM4EMAP4K4TDP1 | |
| SCHEMBL6304413 | 0.74 | KMT2A (1.00) | KMT2AMEN1KDM4EMAP4K4HPGD | |
| SCHEMBL510244 | 0.74 | KMT2A (0.66) | KMT2AMEN1KDM4EMAP4K4TDP1 | |
| SCHEMBL4252380 | 0.73 | MEN1 (0.59) | KMT2AMEN1KDM4EL3MBTL1MLNR | |
| SCHEMBL14659263 | 0.72 | MEN1 (0.48) | KMT2AMEN1KDM4EBRAFL3MBTL1 | |
| SCHEMBL17440373 | 0.72 | KMT2A (0.70) | KMT2AMEN1MAP4K4L3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080099-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2018-04-11 | — | — | EP | disclosed |