Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | MERTK | Q12866 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20041026 | 0.85 | KMT2A (0.59) | KDM4EKMT2AMEN1HSPB1LMNA | |
| SCHEMBL16792729 | 0.82 | MEN1 (0.48) | KDM4EKMT2AMEN1HSPB1SCN9A | |
| SCHEMBL16792509 | 0.80 | KMT2A (0.46) | KDM4EKMT2AMEN1SCN9ASMN1; SMN2 | |
| SCHEMBL18181837 | 0.79 | MEN1 (0.46) | KDM4EKMT2AMEN1HSPB1 | |
| SCHEMBL16792569 | 0.76 | MEN1 (0.71) | KDM4EKMT2AMEN1HSPB1RAB9A | |
| SCHEMBL17244757 | 0.76 | LMNA (0.49) | KDM4EKMT2AAXLSMN1; SMN2NPC1 | |
| SCHEMBL27300363 | 0.72 | ALOX5AP (0.55) | KDM4EKMT2AMEN1HSPB1 | |
| SCHEMBL21902136 | 0.72 | ALDH1A1 (0.64) | KDM4EKMT2AMEN1HSPB1P2RX3 | |
| SCHEMBL27300366 | 0.72 | MEN1 (0.47) | KDM4EKMT2AMEN1HSPB1P2RX3 | |
| SCHEMBL16792611 | 0.72 | MEN1 (0.43) | KDM4EKMT2AMEN1HSPB1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080099-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2018-04-11 | — | — | EP | disclosed |